Which receptors are activated by an increase in interstitial fluid volume?

An increase in interstitial fluid volume predominantly activates J receptors, which are sensitive to changes in interstitial fluid and are located in the lungs. These receptors play a critical role in sensing fluid overload and contribute to the regulation of respiratory patterns and cardiovascular responses. When interstitial fluid volume increases, J receptors are stimulated, leading to the sensation of dyspnea and potentially stimulating reflex pathways to decrease heart rate and reduce blood pressure, thereby attempting to restore hemodynamic balance.

Type B receptors, also known as beta-adrenergic receptors, are primarily involved in the sympathetic nervous system response, affecting heart rate and contractility, but they do not directly respond to changes in interstitial fluid volume. Type A receptors may refer to other specific receptor types, but they are not specifically linked to the regulation of interstitial fluid volume. Baroreceptors, on the other hand, are specialized sensors for arterial blood pressure changes but do not directly respond to changes in interstitial fluid volume; instead, they detect stretch in arterial walls due to changes in blood pressure. Thus, within the context of interstitial fluid volume changes, J receptors are uniquely positioned to respond and contribute to the physiological adaptations needed.