Which class of antihypertensives are African Americans known to have a poor response to?

African Americans are known to have a poor response to ACE inhibitors due to several pharmacogenetic and physiological factors. Research indicates that there is a lower prevalence of the Renin-Angiotensin-Aldosterone System (RAAS) component that is often targeted by ACE inhibitors in this population. Many African Americans have a low-renin profile, resulting in a less effective response to medications that rely on this system to control blood pressure. Consequently, alternative classes of antihypertensives, such as calcium channel blockers and diuretics, tend to be more effective in this demographic. Understanding these differences can help tailor hypertension management more effectively for diverse populations.