What is the most common side effect of nesiritide, a vasodilator with diuretic effects?

Nesiritide is a recombinant form of B-type natriuretic peptide used primarily in the treatment of acute heart failure. Its mechanism of action includes vasodilation and diuresis, which can lead to significant drops in blood pressure due to its effects on the vascular system.

The most common side effect associated with nesiritide is hypotension. This occurs because the drug promotes vasodilation, leading to decreased systemic vascular resistance and a subsequent reduction in blood pressure. Practitioners must monitor blood pressure closely when administering nesiritide, as the goal is to alleviate fluid overload while maintaining adequate perfusion to vital organs.

While peripheral edema, headaches, and electrolyte imbalances can occur as side effects due to the changes in kidney function and fluid balance, hypotension specifically stands out as the primary and more frequently encountered adverse effect with nesiritide usage. Understanding this common side effect is critical for effective patient management in acute care settings.